Accurate Method of HPLC-Ms/Ms Determination of Mycophenolic Acid in Human Plasma
نویسندگان
چکیده
منابع مشابه
Determination of the acyl glucuronide metabolite of mycophenolic acid in human plasma by HPLC and Emit.
BACKGROUND The acyl glucuronide (AcMPAG) of mycophenolic acid (MPA) has been found to possess pharmacologic and potentially proinflammatory activity in vitro. To establish its pharmacologic and toxicologic relevance in vivo, a reversed-phase HPLC method was modified to simultaneously determine MPA, the phenolic MPA-glucuronide (7-O-MPAG), and AcMPAG. In addition, cross-reactivity of AcMPAG in t...
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ژورنال
عنوان ژورنال: Journal of Bioequivalence & Bioavailability
سال: 2016
ISSN: 0975-0851
DOI: 10.4172/jbb.1000316